Description
6-APB
6-(2-aminopropyl)benzofuran (also known as 6-APB or by the brand-name Benzofury) is a popular synthetic entactogen of the phenethylamine and benzofuran chemical classes that produces a powerful, long-lived array of typical MDA-like entactogenic effects such as sedation, enhanced feelings of empathy, love, and sociability, muscle relaxation, anxiety relief and physical and cognitive euphoria when administered.
TECHNICAL INFORMATION
Formal Name
α-methyl-6-benzofuranethanamine, monohydrochloride
CAS Number
286834-84-2
Synonyms
6-(2-Aminopropyl)Benzofuran
Benzo Fury
Molecular Formula
C11H13NO • HCl
Formula Weight
211.7
Purity
≥98%
Formulation
A crystalline solid
λmax
207, 246, 276, 285 nm
SMILES
CC(N)CC1=CC2=C(C=C1)C=CO2.Cl
InChI Code
InChI=1S/C11H13NO.ClH/c1-8(12)6-9-2-3-10-4-5-13-11(10)7-9;/h2-5,7-8H,6,12H2,1H3;1H
InChI Key
APEWOTOLPKNSPE-UHFFFAOYSA-N
6-APB is a serotonin–norepinephrine–dopamine reuptake inhibitor (SNDRI) with Ki values of 117, 150, and 2698 nM for the norepinephrine transporter (NET), dopamine transporter (DAT), and serotonin transporter (SERT), respectively.[1] In addition, 6-APB not only blocks the reuptake of these monoamine neurotransmitters but is also a releasing agent of them; that is, it is a serotonin-norepinephrine-dopamine releasing agent (SNDRA).[2] In addition to actions at the monoamine transporters, 6-APB is a potent full agonist of the serotonin 5-HT2B receptor (Ki = 3.7 nM),[1][1] with higher affinity for this target than any other site.[3] Moreover, unlike MDMA, 6-APB shows 100-fold selectivity for the 5-HT2B receptor over the 5-HT2A and 5-HT2C receptors.[3][4] It is notably both more potent and more selective as an agonist of the 5-HT2B receptor than the reference 5-HT2B receptor agonist, BW-723C86, which is commonly used for research into the 5-HT2B receptor.[citation needed] Aside from the 5-HT2B receptor, 6-APB has also been found to bind with high affinity to the α2C-adrenergic receptor subtype (Ki = 45 nM), although the clinical significance of this action is unknown.[1] 6-APB showed little other affinity at a wide selection of other sites.[1]
The potent agonism of the 5-HT2B receptor makes it likely that 6-APB would be cardiotoxic with chronic or long-term use, as seen with other 5-HT2B receptor agonists such as the withdrawn serotonergic anorectic fenfluramine.[1][5]
Healthplus Research Chemicals are European based company specializing in retails and wholesale distribution of the best Re-find Research Chemicals.
Since our founding, we have been developing a vast catalog of products to meet the needs of our customers. We have grown our capabilities to include active pharmaceutical ingredient manufacturing, forensic analytical standard production, contract research service expertise, pre-clinical drug development, research grant support, and community outreach. Through all these endeavors, we remain committed to our origins and our founding vision: to provide affordable, high-quality products and to serve the research community.
